Karanambu is located about halfway between the Amerindian village of Annai and the border town of Lethem. It is reached via a side road off the main dirt road between these towns, by public airstrip, or by private airstrip adjacent to the lodge. Visitors typically fly into Karanambu one direction and then take the boat either up or down the Rupununi River from Ginep Landing, which lies south of Annai and is nothing more than a boat landing site. Transport can be arranged from Rock View to Ginep Landing at Rock View Lodge.