Fort San Lorenzo National Park is situated just west of the Gatun Locks on the Caribbean side of the Panama Canal. It is reached by crossing Gatun Locks from Colon. Just past the locks is the turnoff toward Fort Sherman and the ruins of the old Spanish fortress of San Lorenzo. This road goes north toward Toro Point and then west along the coast to the fortress.
Going south rather than turning off to Fort Sherman and Fort San Lorenzo brings one to the southern end of the park and eventually to Achiote Road. The southward road skirts Gatun Lake to the east until the turnoff to the village of Achiote where one turns right onto Achiote Road.